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Adolescent girls and young women (AGYW) in the Eastern and Southern Africa Region face serious challenges to fulfilling their sexual and reproductive health and rights, including vulnerability to HIV, sexually transmitted infections and unintended and unsafe pregnancy. The adolescent birth rate in ESAR is twice the global rate, at 92 births per 1,000 girls, and AGYW continue to be at higher risk of HIV compared to adolescent boys and young men.