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This brief provides an overview of the process and emerging results from a triangular cooperation between the UNFPA Asia and the Pacific Regional Office, UNFPA East and Southern Africa Regional Office, and the UNFPA Representation Office in Geneva in 2020/2021 on the engagement with international Human Rights Mechanisms, particularly the Universal Periodic Review (UPR), to advance and drive development cooperation efforts on Sexual and Reproductive Health and Rights. This partnership offers reflections on leadership of the two Regional Offices and Geneva Office to develop resources and tools that can be used by different regions and adapted to virtual and hybrid formats. It shows how the collaboration builds on and strengthens, country capacities to engage meaningfully with the UPR and other human rights mechanisms to implement the commitments made by governments during the Nairobi Summit on ICPD25, and support States in achieving more equitable and sustainable progress in the realisation of human rights.