The Assessment of Adolescent and Youth-Friendly Health Services in the East and Southern Africa Region (2015-2017) was undertaken with the purpose of conducting a review of existing adolescent and youth-friendly health services (AYFHS) policies, guidelines, protocols and standards, and assessing how they are implemented in 23 countries of the East and Southern Africa (ESA) region . The national policies, standards and guidelines on AYFHS of 23 countries were compared with the WHO Global Standards for quality health care services for adolescents (2015).